Prunella Vulgaris Clinical Study Links
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Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes. Taken together, APV suppressed hyperglycemia and diabetic vascular dysfunction in HFHC diet-db/db mice. The pBiological activities of Prunella vulgaris extract.resent data suggest that Prunella vulgaris may prevent development of diabetic atherosclerosis.
Phytochemistry and pharmacological activities of the genus Prunella.
Modern pharmacological studies have revealed that Prunella possess antiviral, antibacterial, anti-inflammatory, immunoregulatory, anti-oxidative, anti-tumor, antihypertensive and hypoglycemic functions.
Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice.
CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a(-/-) mice.
Standardized Prunella vulgaris var. lilacina Extract Enhances Cognitive Performance in Normal Naive Mice.
Our results indicate that EEPV may enhance cognitive function via the activation of various intracellular signaling molecules and the up-regulation of adult hippocampal neurogenesis.
Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice.
The present results suggest that ursolic acid from P. vulgaris enhances sleep duration through GABAA receptor activation and could be a therapeutic candidate for insomnia treatment.
Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells. APV has a beneficial effect by the interaction of Nrf2-mediated NO/cGMP with HO-1, suggesting that Prunella vulgaris may be useful in preventing diabetic atherosclerosis.
The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells.
These results demonstrate that P. vulgaris possesses anti-inflammatory properties and can regulate TNF-α-induced expression of adhesion molecules by inhibiting the p38 MAPK/ERK signaling pathway.
Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway.
CONCLUSIONS: Spica Prunellae possesses a broad range of anti-cancer activities due to its ability to affect STAT3 pathway, suggesting that Spica Prunellae could be a novel potent therapeutic agent for the treatment of CRC.
Effects of triterpenic acid from Prunella vulgaris L. on glycemia and pancreas in rat model of streptozotozin diabetes.
CONCLUSIONS: Triterpenic acid from Prunella vulgaris L. has an anti-diabetic effect, by controlling blood glucose and antioxidants, and has a protective effect on the pancreas.
The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation These results suggest that this compound and P. vulgaris could potentially provide a new natural treatment for diabetic complications. However, further studies on the mechanism of AGE action of caffeic acid ethylene ester (5) and more in vivo evidence from diabetic animals are required.
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